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CASE STUDIES - COLUMBIA UNIVERSITY

By Albert Scharf, Ph.D., and Charles A. Slanetz, Ph. D. college of Physicians and Surgeons
Columbia University, New York, NY   USA
Published in the North American Veterinarian

North American Veterinarian Experiments Prove that IN® Pet Supplement Works

Case Studies

For the clinical experiments in eczema we used a preparation called “IN®”

The Effect of Diet on Dog Skin Conditions

Eczema of undetermined origin is a frequent disease of the dog.  Many theories have been suggested, but it seems that a number of different factors may contribute to more or less symptomatic conditions.  Hormonal factors and especially deficiencies of vitamins or other essential food factors certainly play an important role.  It is not always possible to determine such deficiencies.  Sometimes even though the dog receives a diet complete according to our knowledge, vitamin deficiencies may develop due to impaired absorption or a change in the bacterial intestinal flora of the dog. It is well known that nearly all of the vitamin deficiencies may manifest themselves in abnormal conditions of the skin as, for instance, deficiency of vitamin A, vitamin E, inositol, choline and many others.  Also well known is the relation between unsaturated fatty acids and the skin.  It has been frequently observed that the inclusion of a relatively high amount of fat in the diet has a beneficial effect on dry skin.  However, other circumstances make it inadvisable to include too much fat in the diet of the dog, unless one is sure that the diet contains enough lipotropic factors, i.e., substances that prevent accumulation of excess liver fat and promote proper fat metabolism. 

As it has been shown by various authors, soya lecithin seems to have a strong lipotropic effect and promotes the absorption of vitamin A in man and animal.  Soya lecithin also contains a considerable percentage of the essential unsaturated fatty acids.

Favorable results reported in the treatment of psoriasis and other skin conditions in man with lecithin prompted investigation of a preparation rich in lecithin and vitamins in cases of canine eczema.

Experimental

Before going into further experiments, it was deemed advisable to test the effect of soya lecithin on dogs with regard to possible reactions.  The innocuousness of lecithin in large doses for man, and for rabbits and rats has been proved by numerous investigations.

Choline has been reported to influence production of erythrocytes 4, but McKibbin and others established the minimum requirements of dogs for choline far in excess of the dosage alleged harmful to dogs.  A total of eight dogs fed lecithin at a 2 percent level in a commercial diet for six months showed no unfavorable reactions.  Table 1 gives a few characteristic figures out of many observed in this laboratory, which shows that there are no persistent or significant changes in blood pictures of dogs receiving lecithin.
As we and others have shown in the rat, 5 and Aldersberg and Sobotka in man, 6 lecithin improves vitamin A and carotene absorption and utilization as shown by the vitamin A levels in the blood and vitamin A retention in the liver.  Table II shows the rise of vitamin A in the blood in the dog.  The dogs receiving lecithin show marked increases in the vitamin A level in the blood. 

 

Table I - Influence of Soybean and Egg Lecithin on the Blood Picture of Dogs

 

At Start

   

AFTER 18 DAYS

  
DOGTREATMENT

WGT (KG)

HB%

RBC

WGT(KG)

HB%

RBC

568

Soybean Lecithin

8.6

91

6,040,000

8.9

76

6,570,000

641

Soybean Lecithin

11.6

100

7,000,000

11.8

91

6,200,000

795

Egg Lecithin

9.6

94

6,630,000

9.1

95

4,600,000

796

Egg Lecithin

11.6

91

6,000,000

11.8

81

5,270,000

797

Controls

10.5

80

4,360,000

10.5

78

4,390,000

842

Controls

12.7

70

4,950,000

12.5

72

5,350,000

        

 

 

Table II - Effect of Soybean Lecithin on Vitamin A in the Blood of Dogs

 

 

DOG

SUPPLEMENT

BEFORE TREATMENT

AFTER 4 WEEKS

1

IN®

125

800

2

None

140

225

153

IN®

200

954

154

None

125

280

157

IN®

130

450

158

None

226

125

    

 

Case Reports

From about 100 cases, which we have successfully treated in this way, we selected a number of case reports to demonstrate the effectiveness of soyabean lecithin preparation for the treatment of eczema in the dog.

Case 1.

A three-year old, female beagle developed an eczematiod disease characterized by heavy dandruff and subsequent loss of hair in many areas. No scratching was noticed.  The affected parts were slightly swollen and somewhat sensitive to the touch.  The hair coat was rough and dry. A microscope examination of material from the eczmatoid area failed to show any parasites.  The dog was given IN® daily for four weeks. After seven days, improvement to the hair was noticeable.  Regrowth of hair started after two weeks and the affected areas were no longer sensitive.  Within six weeks, new hair had developed in the previously hair-free areas.  NO recurrence of the skin condition was observed during the next twelve months.

Case 2. 

A five-year-old male beagle had a generalized eczematoid condition with areas of alopecia and scaly dermatitis. His coat was dull and dry. IN® at the rate of ½ ounce daily was fed for six weeks. In two weeks improvement in skin condition and coat was evident. After six weeks on IN®, the skin disorder had completely disappeared and the coat condition was excellent.

Case 3. 

A two-year-old male foxhound developed an eczematoid condition shortly after reaching the laboratories. The skin became rough and dry. Heavy dandruff and some loss of hair followed.  NO skin parasites could be detected. IN was incorporated in his diet for as period of four weeks. The dog showed a 20 Ib. Weight gain in this time.  After three weeks, the hair became sleek and glossy.  There was evidence of regrowth of hair in several regions.  The skin condition did not reoccur during the next 14 months.

Case 4. 

A four-year-old female foxhound developed dermatosis of the neck, shoulders, and back a few days after parturition.  The hair coat became dry and skin rough. Some loss of hair occurred. IN® was given for a period of five weeks. Within a week of when the IN®  feeding was started, the skin and hair showed a definite improvement. After two weeks, regrowth of hair was evident and hair became glossy in appearance.  The puppies were in good health during lactation. The bitch remained in good condition during the observation period of ten months.

Case 5. 

An eight-month-old female cocker spaniel had several areas of alopecia showing a dry eczematoid condition on the head and legs. The coat was dry. The animal had a tendency to scratch itself frequently. IN® was administrated daily for six weeks.  In a week, the scratching had become very infrequent; the coat became shiny and skin tone improved. After six weeks, regrowth of hair at the sites of alopecia was evident. No recurrence of the disorder occurred within six months.

Case 6. 

Two one-year-old Irish setters (littermates) had been treated for advanced sarcopic mange.  One dog (a female) was fed IN® and the other was left untreated as a control.  Four weeks after mange treatment, little change was evident in the control, But the IN® – fed dog improved noticeably, and in eight weeks her coat became thick, glossy, and uniform. No recurrence was observed for a period of one-year following the treatment.

Case 7.

A three-year-old mongrel bitch, terrier type, was nursing a litter of four. Areas of alopecia with indurations and scaly dermatitis were present on the legs, the head, and base of the tail. The coat lacked luster. One-half once of IN® was fed daily for a period of eight weeks, i.e., during lactation. A marked improvement was evident after four weeks.  After eight weeks of IN® feeding, complete regrowth of hair occurred and the coat became glossy.

Case 8. 

A two-year-old male mongrel (Irish terrier/ beagle mix)   reached the laboratory with a dull coat, a slight generalized alopecia, and eczeatoid patches 2 to 4 cm. in diameter in the region of the shoulders. One-half ounce of IN® was fed daily for six-week period. In four weeks, growth of new hair was observed, and in six weeks no alopecia or other skin disorder could be detected. 

Discussion

As can be seen from the above, a diet rich in liecithin and vitamins seems to have been effective in the treatment of a high percentage of cases of eczema of undetermed origin. General improvement of the health of the dog as well as subsidence of nervous irritation often has been observed.  Observation as reported above indicate strongly that eczema of unknown origin is very often dietary deficiency and may be treated as such. It also seems to indicate that lecithin, as a source of various factors essential for the maintenance of the skin, and as a vehicle for better absorption of supplements rich in essential vitamins and food factors, may favorably influence the cause of various skin conditions of the dog.

Summary

Lecithin in combination with vitamins and supplements ( IN®) has been used for the treatment of eczema of unknown origin in the dog world with favorable results.
 

A Supplement for Dogs by I.D. Fratta, DVM

For many decades now, men have sought to follow food diets, which would make them look younger and live longer. Vitamin concentrates; freshNatural Cures for Dog Allergiesvegetables, milk, yogurt and food rich in protein are basic products, which are essential to that kind of good diet.
 
The major achievements in human medicine were probably the results of experiments, which were applied to dogs before they were humans. It was with dogs that it was possible to test the results of administering vitamins and minerals in food diets, and it was in the laboratory where it was found that dogs benefit enormously from scientifically balanced diets; dogs live longer, look better and have plenty of energy, and most of the diseases which are associated with poor diets are eliminated.

IN® has been in the hands of veterinarians for many years:  veterinarians were at first the only ones to proscribe the product. I myself used it with satisfaction 25 years ago when associated with The Institute of Comparative Medicine, Columbia – Presbyterian Medical center, New York. Later it became more generally available and owners of kennels, dog trainers and even owners of single dogs have sent appreciative letters to the producer of the lecithin rich diet supplement which is given in small amounts in addition to regular accustomed feeding. Veterinarians using and recommending IN® will welcome the improved nugget form for ease and effectiveness of administration.

According to my experience with IN® this diet supplement helps balance average diets with vitamin and mineral elements frequently lacking. I am able to confirm that eczematous disease in dogs – mange, alopecia (loss of hair), etc. may completely disappear with regular use of IN®. The old method of applying ointment to the parts of the skin of the dog affected by the disease always gave dubious results, since the dog  would start licking, thus uncovering the lesion; given IN® orally this is not a problem. Now it is well known that in all skin and hair disorders, the lack of hair gloss and the inexplicable loss of hair are best treated from the “inside out” and not from the “outside in” (as in the case with local applications). In some instances, I have achieved success in treating dogs from whom all ointments, salves and ungents had failed. Quite often dogs which were given IN® as a supplement to their diet had in a very short time new beautiful hair and dry skin become normal again. In his book “Veterinary Dermatology” (2nd Edition J.P. Lipincott), Dr. Frank Kral mentions the use of IN given dogs “affected by dry eczema characterized by much dandruff and subsequent loss of hair and in various skin disorders”.

 I have made similar observations and have found that dogs subjected to corticosteroid or cortisone treatments of the so – called “wet eczema” or “summer eczema” will experience faster and better relief when given IN®. Undoubtedly this is due to the combined actions of the vitamins, minerals and polyunsaturated fatty acids together with the phospholipids (lecithin) which it contains.

The same results were obtained with this product by the late Dr. Charles Slanetz in rats treated with corticosterioids: the rats given IN® had a larger amount of antibodies. I have similarly noticed that dogs receiving IN® exhibit an increased resistance to disease. This same experience was reproduced in dogs in research by Dr. Slanetez and Dr. Albert Scharf at Colombia; and in otherwork, Dr. F. Kral (D.M.V.) Professor of Veterinary Medicine, University of Pennsylvania, reported treating various skin disorders, particularly chronic squamouscursted eczema and severe cases of demodectic mange with good supportive results.

Dog Allergies ScratchingI find that IN® supplies dietic factors which the usual dog foods do not supply. A great many vitamins lose their effect during preparation; minerals present often become dissolved and in order to balance the unavoidable deficiencies of food diets, it is necessary to supply vitamins and minerals by other means. Dogs receiving IN® combine the vitamins and minerals with lecithin and show considerable improvement in their overall health, even though their diets were supposedly complete; and Dr. Slanetz found in a number of cases that dogs failing to mate successfully were able after being fed IN® to produce healthy offspring. 

The level of Vitamin A in the blood increases appreciably within four weeks after initiating the use of IN®Although the content of vitamins, minerals and polyunsaturated fatty acids found in the product are important in the diet, I believe that IN® is as effective as it has been proven to be because it combines all these elements in the right proportions with significant intake of phospholipids (lecithin) thus achieving a more perfect functioning of the entire organism.



     
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